1,2,5,6-Tetrahydro-1-methylpyridine-3-carboxylic acid
Arecaidine
CAS: 499-04-7
Molecular Formula: C7H11NO2
1,2,5,6-Tetrahydro-1-methylpyridine-3-carboxylic acid - Names and Identifiers
1,2,5,6-Tetrahydro-1-methylpyridine-3-carboxylic acid - Physico-chemical Properties
| Molecular Formula | C7H11NO2 |
| Molar Mass | 141.17 |
| Density | 1.166±0.06 g/cm3 (20 ºC 760 Torr) |
| Melting Point | 232°C (dec.) |
| Boling Point | 104-112℃ (14-16 Torr) |
| Flash Point | 115.1±25.9℃ |
| Solubility | Dissolution (44g/L) (25°C) |
| Appearance | Powder |
| Color | Plates from dil alc |
| pKa | pKa 9.07(H2O t=25)(Approximate) |
| Storage Condition | Sealed in dry,2-8°C |
| Refractive Index | 1.5026 (estimate) |
1,2,5,6-Tetrahydro-1-methylpyridine-3-carboxylic acid - Risk and Safety
| Toxicity | sce-mus-ipr 1 g/kg/5D-I CALEDQ 23,189,84 |
1,2,5,6-Tetrahydro-1-methylpyridine-3-carboxylic acid - Reference
| Reference Show more | 1. [IF=7.963] Hongmei Huang et al."Occurrence of areca alkaloids in wastewater of major Chinese cities."Sci Total Environ. 2021 Aug;783:146961 2. [IF=3.101] Yunhe Wang et al."Development of a specific monoclonal antibody-based icELISA for detection of arecoline in traditional Chinese medicines and fresh areca nuts."Food Agr Immunol. 2022;33(1):113-126 |
1,2,5,6-Tetrahydro-1-methylpyridine-3-carboxylic acid - Reference Information
| pharmacological action | arecoline lacks the typical parasympathetic action of arecoline, can also affect the behavior of mice, and can reduce the autonomous activity and inquiry behavior of mice. Studies have shown that arectinine and desmethylarectinine have the activity of C- aminobutyric acid (GABA) reuptake inhibitor on rat brain slices. Another study used cat spinal cord slices to show that arecoline can enhance the inhibitory activity of GAGB and B- alanine, while desmethylarecoline can increase the inhibitory activity of GAGB without affecting the activity of glycine. This study also found that intravenous injection of arecoline has no effect on the activity of GAGB, which indicates that arecoline itself may not be able to act through the blood-brain barrier, and the effect of arecoline on the central nervous system may be through The transmitter system other than GAGB works. |
| determination of content | determination of arecoline and arecoline in areca nut by high performance liquid chromatography. Using HPLC method, the chromatographic column is a NucleosilSA cation exchange chromatographic column (4.6mm × 250mm,5 μm), the mobile phase is methanol-water-phosphoric acid (60 ∶ 40 ∶ 0.3, the ammonia test solution is adjusted to pH3.8), the flow rate is 1.0mL • min-1, the detection wavelength is 212nm, and the column temperature is 30 ℃. Results: Arecoline and arecoline were well separated from other components. Arecoline had a good linear relationship in the concentration range of 2.0232.30 μg • mL-1 (R2 = 0.9995), the average recovery rate was 97.2%,RSD was 2.4%(n = 9); Arecoline had a good linear relationship in the concentration range of 0.8513.55 μg • mL-1 (R2 = 0.9993), and the average recovery rate was 103.9%,RSD is 2.6%(n = 9). Conclusion: The established method is specific, accurate and reproducible, and can be used for the determination of arecoline and arecoline in areca catechu. |
| biological activity | Arecaidine, a pyridine alkaloid, is an effective GABA absorption inhibitor. Arecaidine is a substrate for H-coupled amino acid transporter 1 (PAT1,SLC36A1), which competitively inhibits L-proline uptake. |
| category | toxic substances |
| flammability hazard characteristics | combustible; combustion produces toxic nitrogen oxide smoke |
| storage and transportation characteristics | warehouse ventilation and low temperature drying |
| fire extinguishing agent | dry powder, foam, sand, carbon dioxide, mist water |
Last Update：2024-04-09 21:31:59
Supplier List
Featured ProductsSpot supply
Product Name: Arecaidine Visit Supplier Webpage Request for quotationCAS: 499-04-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Arecaidine Visit Supplier Webpage Request for quotationCAS: 499-04-7
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Featured ProductsSpot supply
Product Name: Arecaidine Visit Supplier Webpage Request for quotationCAS: 499-04-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Arecaidine Visit Supplier Webpage Request for quotationCAS: 499-04-7
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
View History